Comparison of meloxicam and a glucosamine-chondroitin supplement in management of feline osteoarthritis
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A double-blind randomised, placebo-controlled, prospective trial
R. M. Sul; D. Chase; T. Parkin; D. Bennett Small Animal Clinical Sciences, School of Veterinary Medicine, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, Scotland, UK
Feline, osteoarthritis, glucosamine, chondroitin, meloxicam
To compare the efficacy of meloxicam and a glucosamine-chondroitin (GluCh) supplement in the management of feline osteoarthritis (OA).
Prospective, blinded, randomized clinical trial. Cats over eight years of age with clinical signs of chronic OA were assigned to one of two groups and Glu-Ch or meloxicam was administered orally for 70 days, followed by a placebo until day 98. Cats were assessed by a veterinarian on five occasions and the owner completed an assessment form at the same time.
Data were collected from thirty cats. Pre-treatment disease scores were significantly higher in the meloxicam group for owner mobility (p = 0.01) and veterinary lameness (p = 0.02). Owner mobility scores at day 14 (p = 0.01) and day 42 (p = 0.002) were significantly improved compared to pre-treatment scores for the meloxicam group. When meloxicam and Glu-Ch were discontinued and the placebo commenced, a significant proportion of the meloxicam group showed worsening of all the owner- assessed scores between day 70 and day 98, when compared to the Glu-Ch group (mobility p = 0.01; activity p = 0.02; temperament p = 0.04; lifestyle p = 0.01).
Treatment with meloxicam resulted in a significant improvement in mobility and activity levels of cats with OA until the placebo was introduced. A greater proportion of cats receiving meloxicam medication showed a significant worsening of owner assessment scores once the placed was introduced, when compared to the Glu-Ch group.